Hypertension in Pregnancy: The Role of Circulating Endothelial Progenitor Cell Dysfunction
نویسنده
چکیده
Pregnancy-induced hypertension (PIH) development associates well with considerable abnormalities in the structure and function of vascular endothelium. Lowered number and weak function of circulating endothelial progenitor cells (EPCs) as a marker of worsening endothelial integrity were recognized a promising indicator of PIHrelated clinical outcomes. Although there are limiting data regarding predictive usefulness of serial EPC count measurement in pregnant women, it has been postulated that EPC dysfunction could be got better prognostication than other biomarkers including serum inflammatory cytokines, von Willebrand factor, E-selectin in prediction of some severe PIH-related states, i.e., fetoplacental insufficiency and premature parturitions. The sort communication is depicted the role of EPC dysfunction as a promising biomarkers in PIH.
منابع مشابه
Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases
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Endothelial damage/dysfunction and hypertension in pregnancy.
Hypertension is one of the most common medical conditions complicating pregnancy, with significant implications on maternal and perinatal morbidity and mortality. Abnormalities in placentation have been implicated as the primary pathology responsible for the development of hypertension during pregnancy and its effects such as pre-eclampsia and eclampsia. With advancing research, the focus is no...
متن کاملThe Role of Circulating Endothelial Progenitor Cell Dysfunction in Pregnancy-Induced Hypertension
Pregnancy-induced hypertension (PIH) development associates well with considerable abnormalities in the structure and function of vascular endothelium. Lowered number and weak function of circulating endothelial progenitor cells as a marker of worsening endothelial integrity were recognized a promising indicator of PIH-related clinical outcomes. Although there are limiting data regarding predic...
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